U1162 Lab – A Multidisciplinary, Young & Motivated Team

Brief history of the team

UMR1162 directed by Jessica Zucman-Rossi, “Functional genomics of solid tumors”, was created in 2005, as Inserm U674, it was renewed in 2009 and 2014, ranked “incontournable” by Inserm as a mixed structure endorsed by four entities: Inserm, Universities Paris Diderot, Paris Descartes and Paris Nord. It is currently located at the University Hematology Institute site in a building managed by the CEPH (Centre d’Etude du Polymorphisme Humain, Foundation Jean Dausset).

Jessica Zucman-Rossi, is professor of Medicine in Oncology (PUPHex) at university Paris Descartes and HEGP, full time for research. She directed the Inserm U674 and U1162 since 2007, was chairman of the Inserm scientific committee devoted to Oncology, Genetics and Bioinformatics from 2012 to 2016. She is editor at Journal of Hepatology (IF=12.4), executive secretary of the International Liver Cancer Association (ILCA). She published 157 original papers and has an international recognition in the field of genomics of human cancers and more specifically in liver tumors.

 

 

 

Our missions

Our mission is to develop basic genomic approaches based on human tumors analyses to identify new mechanisms of tumorigenesis and to transfer this knowledge into biomarkers and therapeutic targets that could be introduced in clinical care. In particular, we aim to identify new genomic alterations and mechanisms of carcinogenesis. We also aim to identify new risk factors and genetic predispositions promoting the development of tumors. Our general strategy is based on the omic’s analyses of large cohorts of patients with liver tumors (benign and malignant), mesothelioma and clear cell renal carcinoma. The group was pioneer in the elucidation of the molecular classification of benign and malignant liver tumors. Then we perform (1) functional validation using cell and animal models and (2) we translate our findings into the clinics to improve surveillance, diagnosis, prognosis, treatment and follow-up of the patients.

 

Our task forces

The team include a total of 39 peoples  with an assistant, Many Douang (Inserm), in charge of the budget, human resource, hygiene and safety, training, and 4 groups with their founded projects:

Involvement in French cancer consortiums

 Financial supports from public interest organizations

  

Administrative & Assistant Team

Many DOUANG
Administrator & Assistant
Inserm
Emmanuel BEBLI
Laundry Agent
Inserm
Yannick LADEIRO
PhD
Project Manager Inserm