New paper in Gastroenterology & our Liver Cancer Cell Lines Database

The last work of Sandra Rebouissou group is newly accepted for publication in Gastroenterology.

Entitled, “Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response” it is the first study to provide a comprehensive molecular characterization of most widely used liver cancer cell lines. All the data are available at : www.lccl.zucmanlab.com

Article available on Gastroenterology website.

 

 

 

 

New Publication in Nature Communications from Didier Jean group

Yuna Blum, from Ligue National Contre le Cancer and Didier Jean group used a deconvolution approach and show that molecular gradients shed new light on the intra-tumor heterogeneity of malignant mesothelioma.

 

Malignant pleural mesothelioma (MPM) is recognized as heterogeneous based both onhistology and molecular profiling. Histology addresses inter-tumor and intra-tumor hetero-geneity in MPM and describes three major types: epithelioid, sarcomatoid and biphasic, acombination of the former two types. Molecular profiling studies have not addressed intra-tumor heterogeneity in MPM to date. Here, we use a deconvolution approach and show thatmolecular gradients shed new light on the intra-tumor heterogeneity of MPM, leading to areconsideration of MPM molecular classifications. We show that each tumor can bedecomposed as a combination of epithelioid-like and sarcomatoid-like components whoseproportions are highly associated with the prognosis. Moreover, we show that this moresubtle way of characterizing MPM heterogeneity provides a better understanding of theunderlying oncogenic pathways and the related epigenetic regulation and immune andstromal contexts. We discuss the implications of thesefindings for guiding therapeuticstrategies, particularly immunotherapies and targeted therapies.

 

 

Read more 

 

Jessica Zucman-Rossi-Rossi-Rossi in the last Médecine/Sciences video.

After having published the excellent booklet devoted to the portraits of “40 remarkable women scientists”, Médecine/Sciences continues to put women in the spotlight by opening a new video section on its website, “Les entretiens de m/s”, which features women scientists for their first cycle whose dynamism and passionate commitment are communicative. Jessica, our director had the opportunity to talk about liver tumors and women in sciences trough this interview!