New publication by Didier Jean team in Lung Cancer

Didier Jean team have just published a new paper in Lung Cancer. In this work the investigated anti-tumor effect of eight major signaling pathways inhibitors involved in malignant pleural mesothelioma (MPM) carcinogenesis. They found that three inhibitors were more efficient than cisplatin, the drug used as first-line chemotherapy in patients with MPM: verteporfin, a putative YAP inhibitor, defactinib, a FAK inhibitor and NSC668394, an Ezrin inhibitor.

Verteporfin, the most efficient inhibitor, induced cell proliferation arrest and cell death, and is effective on 3D spheroid multicellular model. Verteporfin sensitivity was YAP-independent and related to molecular classification of the tumors. Biomarkers based on gene expression were identified to predict accurately sensitivity to these three inhibitors.

Link to the publication 


René & Andrée Duquesne 2018 Price to Pr Jessica Zucman-Rossi and her team!

We are very proud to receive, with Pr Pascale COSSART,  the 2018 René & Andrée Price from Ligue Contre le Cancer past  Monday at Institut Pasteur.



First HTE Program Workshop : Organoïds & 3D cultures – May 16 2018

We organized the 1st HTE Program Workshop in our building May 16th 2018, 10h-17h.

This first edition is free and will focus on organoïds and 3D cultures for the tumors heterogeneity studies. HTE Program partners and invited speakers will present their expertise in the field. A poster session will take place at the lunch and the day will end by a round table with the attendance.

Venue: Foundation Jean Dausset,  27 rue Juliette Dodu 75010 Paris.

Metro 2 : Colonel Fabien / Bus 46 or 75 : Grange Aux Belles/ Juliette Dodu

Agenda :

  • Stéphanie DESCROIX (Institut Curie – Paris)
  • Giovanni CAPPELO (CNRS – Grenoble Alpes University)
  • Pierre NASSOY (CNRS – LP2N – Institut d’Optique d’Aquitaine)
  • Francesco PAMPALONI (Franckfort University)













Please feel free to register on this link :