Don’t forget the 2nd HTE Workshop organized by Olivier Saut (INRIA Bordeaux) and Yannick Ladeiro from our lab. This event is organized in the field of HTE Program, coordinated by our team leader, Jessica Zucman-Rossi, and will focus on mathematical and computer modeling in order to study tumoral heterogeneity.
Registration is free but required. Only 15 place left so register quickly!
Didier Jean team have just published a new paper in Lung Cancer. In this work the investigated anti-tumor effect of eight major signaling pathways inhibitors involved in malignant pleural mesothelioma (MPM) carcinogenesis. They found that three inhibitors were more efficient than cisplatin, the drug used as first-line chemotherapy in patients with MPM: verteporfin, a putative YAP inhibitor, defactinib, a FAK inhibitor and NSC668394, an Ezrin inhibitor.
Verteporfin, the most efficient inhibitor, induced cell proliferation arrest and cell death, and is effective on 3D spheroid multicellular model. Verteporfin sensitivity was YAP-independent and related to molecular classification of the tumors. Biomarkers based on gene expression were identified to predict accurately sensitivity to these three inhibitors.
We are very proud to receive, with Pr Pascale COSSART, the 2018 René & Andrée Price from Ligue Contre le Cancer past Monday at Institut Pasteur.
Remise du Prix René et Andrée Duquesne de @LigueCancer75 hier à l' @institutpasteur au Professeur Jessica ZUCMAN -ROSSI pour ses travaux remarquables sur les #cancers hépatiques. pic.twitter.com/9bEAQwi4JM
— Ligue Cancer Paris (@LigueCancer75) 11 septembre 2018
Tomorrow, we take part of the first HTE Program Workshop organization.
Due to the huge success of the topic registrations are already closed. If you are registered we can’t wait to see you tomorrow at the “Musée des Moulages” in Saint Louis Hospital.
Registrations are free but required on HTE Program website.
The high level program is finally available below, don’t miss our experts.
We organized the 1st HTE Program Workshop in our building May 16th 2018, 10h-17h.
This first edition is free and will focus on organoïds and 3D cultures for the tumors heterogeneity studies. HTE Program partners and invited speakers will present their expertise in the field. A poster session will take place at the lunch and the day will end by a round table with the attendance.
Venue: Foundation Jean Dausset, 27 rue Juliette Dodu 75010 Paris.
Metro 2 : Colonel Fabien / Bus 46 or 75 : Grange Aux Belles/ Juliette Dodu
Agenda :
Please feel free to register on this link :