Our PhD students are broadly implicated in association ADELIH. They organized a high level congress each year. The next one will take place soon the 29 & 30 March 2018
Come and join them at Chimie Paris Tech to learn more about : THE ORIGIN OF CANCER: once upon a cell…
FunGeST Lab – A Multidisciplinary, Young & Motivated Team
Brief history of the team
FunGeST “Functional genomics of solid tumors”, directed by Jessica Zucman-Rossi, was created in 2005, as Inserm U674, it was renewed in 2009, 2014 as UMR1162, ranked “incontournable” by Inserm as a mixed structure endorsed by four entities: Inserm, Universities Paris Diderot, Paris Descartes and Paris Nord. It is currently located at the University Hematology Institute site in a building managed by the CEPH (Centre d’Etude du Polymorphisme Humain, Foundation Jean Dausset). Since January 2019, the lab take part of Centre de Recherche des Cordeliers Research Center – Inserm UMR S1138, and as been recently renewed in January 2024.
Jessica Zucman-Rossi, is professor of Medicine in Oncology (PUPHex) at the University Paris Descartes and HEGP, dedicated full-time for research. She has directed the Inserm U674, U1162, and UMRS1138 FunGeST team since 2007, and served as chairman of the Inserm scientific committee devoted to Oncology, Genetics and Bioinformatics from 2012 to 2016. She is editor at the Journal of Hepatology (2023 IF=26.8), and the executive secretary of the International Liver Cancer Association (ILCA). She is internationally recognized in the field of genomics of human cancers, and particularly in liver tumors. Since January 2019, Pr. Zucman-Rossi has been the director of the Cordeliers Research Center, and was renewed for another 5-years in 2024.
Our missions
Our mission is to develop basic genomic approaches based on human tumors analyses to identify new mechanisms of tumorigenesis and to transfer this knowledge into biomarkers and therapeutic targets that could be introduced in clinical care. In particular, we aim to identify new genomic alterations and mechanisms of carcinogenesis. We also aim to identify new risk factors and genetic predispositions promoting the development of tumors. Our major fields of research are related to liver tumors, mesothelioma and HPV-related cancers, mainly in adults but also in children for liver tumors.
Our team is multidisciplinary mixing basic researchers in genomics, genetics, cell biology, and bioinformatics with clinicians.
Our approach
Our major topics are all centered on “bench to bedside” discoveries and vice versa:
the identification of new cancer
driver genes and tumor molecular classification to identify new therapeutic
targets functionally validated
to be translated into therapeutic targets and improve
clinical management of the patients,
the identification of genetic
markers associated with cancer development to better predict the individual
risk of cancer occurrence,
understanding gene-environment interactions to identify early oncogenic
events and improve cancer prevention,
the identification of viral-induced cancer
secondary to HPV, HBV, HCV, and AAV infections,
to understand the
bases of tumor heterogeneity and evolution
to identify mechanisms of resistance to treatment using integrated strategies.
Our
strategies are based on large tumor collections with extensive clinical
annotation (PRB Hôpitaux Universitaires Paris-Seine-Saint Denis, M Ziol, and
other CRB at APHP hospitals and a national network), the development of
innovative integrative genomic analyses, and the transfer into clinical care
for the benefit of the patients. We
are also actively developing productive scientific collaborations at CRC,
regional, national, international, and industrial levels.
Our task forces
The team include a total of 45 peoples organized in 6 groups with their founded projects:
“Functional Genomics of Liver tumors” led by Jessica Zucman-Rossi focusing on the characterization of genomic alterations in benign and malignant liver tumors, functional validation, identification of new risk factors and genetic predisposition and translation to the clinics.