Our Public Data


Gastroenterology – Caruso et al – Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response.


Item Data Details
Cell lines LCCL_description Description of liver cancer cell lines.
Cell lines Somatic_alterations List of putative somatic genomic alterations identified in 34 Liver Cancer Cell Lines by whole-exome sequencing.
Cell lines Fusion_transcripts Fusion transcripts identified in 34 liver cancer cell lines by RNA-sequencing.
Cell lines HBV_fusions HBV RNA fusions identified by RNA-sequencing among 34 liver cancer cell lines.
Cell lines Drivers List of the 252 cancer driver genes used to analyze association between drug sensitivity and genetic alterations in 34 liver cancer cell lines.
Cell lines RNAseq_vsn RNA expression in 34 liver cancer cell lines (vsn)
Cell lines RNAseq_FPMK RNA expression in 34 liver cancer cell lines (FPKM)
Cell lines microRNAseq_vsn microRNA expression in 34 liver cancer cell lines (vsn)
Cell lines microRNAseq_RPM microRNA expression in 34 liver cancer cell lines (RPM)
Cell lines Protein_expression Expression of 126 proteins analyzed by RPPA in 34 liver cancer cell lines (log2-transformed).
Cell lines/Drugs AUC Drug sensitivity in 34 liver cancer cell lines. Table of AUC values for each drug
Cell lines/Drugs GI50 Drug sensitivity in 34 liver cancer cell lines. Table of GI50 values for each drug
Drugs Screened_compounds Description of screened compounds.

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Our Lab

FunGeST Lab – A Multidisciplinary, Young & Motivated Team

Brief history of the team

FunGeST “Functional genomics of solid tumors”, directed by Jessica Zucman-Rossi, was created in 2005, as Inserm U674, it was renewed in 2009 and 2014 as UMR1162, ranked “incontournable” by Inserm as a mixed structure endorsed by four entities: Inserm, Universities Paris Diderot, Paris Descartes and Paris Nord. It is currently located at the University Hematology Institute site in a building managed by the CEPH (Centre d’Etude du Polymorphisme Humain, Foundation Jean Dausset). Since January 2019, the lab take part of Centre de Recherche des Cordeliers  Research Center – Inserm UMR S1138 as team 28.

Jessica Zucman-Rossi, is professor of Medicine in Oncology (PUPHex) at university Paris Descartes and HEGP, full time for research. She directed the Inserm U674,  U1162 and UMRS1138 – team 28 since 2007, was chairman of the Inserm scientific committee devoted to Oncology, Genetics and Bioinformatics from 2012 to 2016. She is editor at Journal of Hepatology (IF=12.4), executive secretary of the International Liver Cancer Association (ILCA). She published 157 original papers and has an international recognition in the field of genomics of human cancers and more specifically in liver tumors. Since January 2019 Pr Zucman-Rossi-Rossi is the director of the Cordeliers Research Center.

Our missions

Our mission is to develop basic genomic approaches based on human tumors analyses to identify new mechanisms of tumorigenesis and to transfer this knowledge into biomarkers and therapeutic targets that could be introduced in clinical care. In particular, we aim to identify new genomic alterations and mechanisms of carcinogenesis. We also aim to identify new risk factors and genetic predispositions promoting the development of tumors. Our general strategy is based on the omic’s analyses of large cohorts of patients with liver tumors (benign and malignant), mesothelioma and clear cell renal carcinoma. The group was pioneer in the elucidation of the molecular classification of benign and malignant liver tumors. Then we perform (1) functional validation using cell and animal models and (2) we translate our findings into the clinics to improve surveillance, diagnosis, prognosis, treatment and follow-up of the patients.

Our task forces

The team include a total of 39 peoples  organized in 5 groups with their founded projects:

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